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Scientific Program (Preliminary)

Sunday 18.5.2014

16:00-18:30 Registration and Poster Set-Up
18:30-19:00 Welcome
19:00-19:30 C. Barlos- The history of a global peptide manufacturing and technology company CBL and drug synthesis, Greece 

19:30-20:00 N. Peristianis- Education in Cyprus
20:00-22:00 Welcome Drinks Reception
Monday 19.5.2014
8:00-8:30 Registration
8:30-8:45 Welcome by the Chairmen

Chair   C. Glaubitz and A.Yaghur

A. Yaghmur- Lipidic Soft self-assembled drug nanocarriers: cubosomes, hexosomes, and in situ formation of cubic and hexagonal liquid crystalline phases, Denmark
9:30-10:15 S. Charlton-Observed drug-receptor association rates are governed by membrane affinity: The importance of establishing micro PK/PD Relationships, Novartis, UK

10:15-10:45 Coffee Break

10:45-11:30 C. Glaubitz-The potential of solid-state NMR in drug research: Examples from GPCRs and Multidrug Effliux Pumps, IBMRZ, Germany
S. NoskovGating Pathways in Secondary Transporters from NSS family, Canada
12:15-12:30  M. Zervou - Insights into the molecular basis of action of the AT1 antagonist losartan using a combined NMR spectroscopy and computational approach, Greece

12:30 - 13:30 POSTER SESSION

13:30 - 15:00
Lunch Time

R. Hubbard and M. Zervou

15:00-15:45 R. Hubbard - UK Current perspectives in fragment-based drug discovery, UK

15:45-16:00 T. Mavromoustakos - Honorium to Prof. A. Makriyannis 

16:00-16:30 Coffe Break

16:30-17:15 Raymond G. Booth- Serotonin 5-HT2 Receptor Structure-Based Drug Design Leads to Clinical Candidates for Neuropsychiatric Disorders, USA
17:15-18:00 Gregor Mali - Structural and dynamical properties of indomethacin molecules embedded within the mesopores of silicates and metal-organic framework materials : a solid-state NMR view, Slovenia

Tuesday 20.05.2014


Chair Chair S. Noskov, G. Archontis

9:00-9:30 G. Melagraki, A. Afantitis, Targeting promising inhibitors for HCV: A multi step chemoinformatics approach, Cyprus
9:30-10:00 Vasilis J. Promponasa, Constantinos S. Pattichis, Andreas I, ConstantinouaA Scientific Workflow Management System for Virtual Screening in Cancer Chemoprevention, Cyprus

10:00-10:30 Coffee Break

10:30-11:00 G.Archontis, Molecular Dynamics in Drig Design: Development of Compstatin-based Compounds for the Regulation of the Key Complement System Protein C3,Cyprus
11:00-11:30 M. Papadopoulos The mechanism of binding of aspartic proteases, Greece

11:30-11:45 Mary Patricia Yannakakis, Tselios Theodoros- Structure-based design of non-peptide mimetics for the treatment of Multiple Sclerosis, Greece 
11:45-12:00 Tapeinou Anthoula, Tselios Theodoros- . Novel approach in Multiple Sclerosis treatment, Greece

12:00-13:00 POSTER SESSION

13:00-14:00 Lunch Time

Chair   E. Mikros and J. Plavec

14:00-14:05 E. Mikros-A brief overview of the NMR status in the medical applications University of Athens, Greece
14:05-14:35 E. Mikros-NMR metabolomics in diagnosis and toxicology, Greece
14:35-15:20 J. Plavec-NMR structures and cation binding of G-quadruplexes with unique features National Chemistry Institute, Slovenia

15:20-15:50 Coffee Break

15:50-16:20 S. 
S. Golic Grdadolnik-NMR-assisted discovery of novel inhibitors of protein targets: towards new therapeutic agents, Slovenia
16:20-16:50 G. Spyroulias-Insights on the conformational plasticity of drug-targets proteins University of Patras, Greece
16:50-17:20 A. Tzakos- Sculpting stereoelectronic tuning to analogues selectively targeting the AT2 receptor and their potential as very potent agents in breast cancer, Greece

17:20-17:30 Kordopati  Golfo, Conformational studies of LHRH analogue conjugated with cyclodextrin using 2D NMR and Molecular Modeling, Greece
17:30-17:45 M. Birkou, NMR structure and function of the mutated forms of the RING-H2 domain of Arkadia
17:45-18:00 Ai. TsikaStructural nmr study of FOUR VIRAL macro domains


Wednesday 21.05.2014

D. Logothetis and P. Koutentis

8:30-9:15 D. Logothetis -  Targeting a heteromeric Glutamate/Serotonin GPCR complex involved in psychosis, USA
9:15-9:45 P. A. Koutentis - Synthesis of biological compounds against Alzheimer disease, Cyprus

9:45-10:15 S. Nikas, Novel Cannabinergic Ligands, USA

10:15-10:45 Coffee Break

10:45-11:15 I S. Patrikios - Systems Medicine, Applying Systems Biology Approaches for Manipulation of Altered Biomechanisms’ towards Multiple Sclerosis Treatment by the Use of Specific Structured Μolecules and Antioxidant Vitamins: the PLP10 intervention Paradigm, Cyprus
11:15-11:45 Anastasis StephanouNatural Products for Cancer Treatment: Tripterygium wilfordii and Amygdalin Promotes cell death in Cancer Cells but not Normal Cells, Cyprus


Thursday  22.05.2014


Chair: A. Gruzman and M. Cleanthous
8:00-8:45 A. Gruzman - Poly-aromatic heterocyclic AMPK activators: the new platform for developing of bifunctional drugs against type two diabetesIsrael
8:45-9:15 M. Phylactides - Effect of metal ions on fetal haemoglobin induction by hydroxyurea in erythroid cell cultures, Cyprus
9:15-10:00 Khondaker Miraz Rahman- Targeting Transcription Factors with DNA Interactive Small Molecules, UK

10:00 -10:30 Coffee Break

Chair: Khondaker Miraz Rahman, M. Zervou
10:30-10:45 - C. Potamitis, 
Novel Inhibitors for the Aspartic Protease Endothiapepsin by Combining
Structure-Based Design, Dynamic Combinatorial Chemistry and STD-NMR Spectroscopy.

, Greece 
10:45-11:15- M.DemetriadesDynamic Combinatorial Mass Spectrometry:
a powerful tool for quick identification of selective 2-oxoglutarate oxygenases inhibitors
, United Kingdom
11:15-11:30T. MasiniDe novo fragment-based design of inhibitors of DXS guided by Spin-diffusion-based NMR spectroscopy, Netherlands
11:45-12:00- B.Miroslaw, Copper Coordination Compounds As Antimicrobial Agents, Poland
12:00-12:15- Anna Tsantili-Kakoulidou, Fraction Lipophilicity Index (FLI):
A metric for assessing oral drug likeness of ioniazable chemical entities
, Greece
12:15-12:30- O. Provo New antivascular agents in the combretastatin A-4 series, France
12:30-13:00  A. Keramidas, C. Drouza, E. Maltezou, A. Odysseos, Tocopherol/Tocotrienol –Carboxylate Functionalized Conjugated Compounds with Apoptotic/Anticancer Properties, Cyprus
13:00- 13:30    Ο. Zach Odeh, The Design and Evaluation of a Multi level Cross Flow Filtration Microfluidic Device for the Separation of Human Blood Cells.
13:30-13:35     First prize poster award.
13:35-13:40     Second prize poster award.
13:40-13:45     Third prize poster award.

Closing remarks by the chairmen
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